Application

Western Blot (Snap i.d.™) Analysis: 0.5 µg/mL from a previous lot detected LKB1 on 10 µg of NIH/3T3 treated with forskolin lysate.

This Anti-phospho LKB1 (Ser431) Antibody is validated for use in WB for the detection of phospho LKB1 (Ser431).

General description

LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome.

Immunogen

Epitope: Phosphorylated Ser431

KLH-conjugated linear peptide corresponding to human LKB1 when phosphorylated at Ser431.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected LKB1 on 10 µg of NIH/3T3 cell lysate.

Specificity

This antibody recognizes LKB1 when phosphorylated at Ser431.

Target description

~ 55 kDa observed